Keratosis pilaris rubra successfully treated with topical sirolimus: Report of a case and review of the literature

Pediatr Dermatol. 2022 May;39(3):429-431. doi: 10.1111/pde.14963. Epub 2022 Mar 1.

Abstract

Keratosis pilaris rubra (KPR) is a subtype of keratosis pilaris (KP) presenting with numerous "grainlike" follicular papules in a background of confluent erythema most often affecting the face and upper extremities with persistence beyond puberty. Treatment has remained challenging with inconsistent benefit from topical therapies such as emollients, keratolytics, corticosteroids, and retinoids, though case reports documenting success with pulsed dye laser therapy have been found. We present a case of KPR in a 15-year-old boy who was successfully treated with topical sirolimus 1% cream.

Keywords: adolescent; face; keratosis pilaris; sirolimus; topical administration.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abnormalities, Multiple*
  • Adolescent
  • Darier Disease* / drug therapy
  • Emollients
  • Exanthema*
  • Eyebrows / abnormalities
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Pityriasis Rubra Pilaris*
  • Sirolimus / therapeutic use

Substances

  • Emollients
  • Immunosuppressive Agents
  • Sirolimus

Supplementary concepts

  • Burnett Schwartz Berberian syndrome