Owing to the limited stroke of piezo stacks, compliant amplification mechanisms are widely employed to magnify the displacement of piezoelectric actuators for emerging applications in precision engineering. In this study, a three-dimensional (3D) bridge-type amplification mechanism composed of two serially connected bridge-type amplifiers with a novel constraint form has been developed. The parallel guiding beams mounted at the input and output ends significantly increase the lateral stiffness and minimize parasitic displacements for higher accuracy. Furthermore, a new theoretical model is established to predict the magnification behavior of the 3D amplifier that takes into account the displacement loss caused by the coupling of the two bridge-type amplifiers. The accuracy of this model and the mechanical performance of the developed amplifier are verified by conducting finite element simulations and experimental studies on the manufactured prototypes.