Targeting solute carriers to modulate receptor-ligand interactions

Trends Pharmacol Sci. 2022 May;43(5):358-361. doi: 10.1016/ Epub 2022 Feb 26.


Solute carrier transporters (SLCs) limit receptor activation via uptake of extracellular ligands. Novel concepts are emerging that describe the modulation of intracellular and plasma membrane receptors by ligand influx and efflux via SLCs, respectively. Here, we evaluate recent insights and provide an outlook for developing potential therapeutic strategies.

Keywords: drug discovery; receptor; solute carrier; transporter.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Transport
  • Cell Membrane / metabolism
  • Humans
  • Ligands
  • Membrane Transport Proteins* / metabolism
  • Solute Carrier Proteins* / metabolism


  • Ligands
  • Membrane Transport Proteins
  • Solute Carrier Proteins