A review on Tsukushi: mammalian development, disorders, and therapy

Arif Istiaq; Kunimasa Ohta

doi:10.1007/s12079-022-00669-z

A review on Tsukushi: mammalian development, disorders, and therapy

J Cell Commun Signal. 2022 Dec;16(4):505-513. doi: 10.1007/s12079-022-00669-z. Epub 2022 Mar 1.

Authors

Arif Istiaq^{1

2

3}, Kunimasa Ohta⁴

Affiliations

¹ Department of Stem Cell Biology, Faculty of Arts and Science, Kyushu University, 819-0395, Fukuoka, Japan.
² Department of Brain Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, 860-8555, Kumamoto, Japan.
³ HIGO Program, Kumamoto University, 860-8555, Kumamoto, Japan.
⁴ Department of Stem Cell Biology, Faculty of Arts and Science, Kyushu University, 819-0395, Fukuoka, Japan. ohta9203@artsci.kyushu-u.ac.jp.

Abstract

Tsukushi (TSK), a leucine-rich peptidoglycan in the extracellular compartment, mediates multiple signaling pathways that are critical for development and metabolism. TSK regulates signaling pathways that eventually control cellular communication, proliferation, and cell fate determination. Research on TSK has become more sophisticated in recent years, illustrating its involvement in the physiology and pathophysiology of neural, genetic, and metabolic diseases. In a recent study, we showed that TSK therapy reversed the pathophysiological abnormalities of the hydrocephalic (a neurological disorder) brain in mice. This review summarizes the roles of TSK in key signaling processes in the mammalian development, disorders, and evaluating its possible therapeutic and diagnostic potential.

Keywords: Biomarker; Hydrocephalus; Mammalian development; SLRP; Therapy; Tsukushi; Wnt signaling.

Publication types

Review