A review on Tsukushi: mammalian development, disorders, and therapy

J Cell Commun Signal. 2022 Mar 1. doi: 10.1007/s12079-022-00669-z. Online ahead of print.


Tsukushi (TSK), a leucine-rich peptidoglycan in the extracellular compartment, mediates multiple signaling pathways that are critical for development and metabolism. TSK regulates signaling pathways that eventually control cellular communication, proliferation, and cell fate determination. Research on TSK has become more sophisticated in recent years, illustrating its involvement in the physiology and pathophysiology of neural, genetic, and metabolic diseases. In a recent study, we showed that TSK therapy reversed the pathophysiological abnormalities of the hydrocephalic (a neurological disorder) brain in mice. This review summarizes the roles of TSK in key signaling processes in the mammalian development, disorders, and evaluating its possible therapeutic and diagnostic potential.

Keywords: Biomarker; Hydrocephalus; Mammalian development; SLRP; Therapy; Tsukushi; Wnt signaling.

Publication types

  • Review