Louder for longer: Myc amplifies gene expression by extended transcriptional bursting

Cell Rep. 2022 Mar 1;38(9):110470. doi: 10.1016/j.celrep.2022.110470.


Transcription is a complex, dynamic process. Using live single-cell measurements, Patange et al. show, in a recent issue of Cell Reports, that elevated levels of the transcription factor MYC enhance target gene RNA production by increasing the duration but not frequency of transcriptional bursts.

Publication types

  • Comment

MeSH terms

  • Gene Expression
  • Gene Expression Regulation*
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism


  • Transcription Factors