The Spectrum of Airway Involvement in Inflammatory Bowel Disease

Clin Chest Med. 2022 Mar;43(1):141-155. doi: 10.1016/j.ccm.2021.12.003.


Inflammatory bowel disease is associated with a wide spectrum of central, large, and small airway abnormalities, including bronchiectasis. The bronchiectasis associated with inflammatory bowel disease has a distinct phenotype, with marked inflammation and at times severe sterile bronchorrhea that can be responsive to inhaled corticosteroids.

Keywords: Airways disease; Bronchiectasis; Bronchiolitis; Bronchitis; Bronchorrhea; Bronchoscopy; Crohn; Extraintestinal manifestation; Inflammatory bowel disease; Purulent sputum; Small airways disease; Tracheitis; Ulcerative colitis; Upper airway obstruction.

Publication types

  • Review

MeSH terms

  • Bronchiectasis* / etiology
  • Chronic Disease
  • Humans
  • Inflammation
  • Inflammatory Bowel Diseases* / complications
  • Inflammatory Bowel Diseases* / drug therapy
  • Phenotype