Positron Emission Tomography in Atherosclerosis Research

Methods Mol Biol. 2022:2419:825-839. doi: 10.1007/978-1-0716-1924-7_50.


Positron emission tomography (PET) is a quantitative imaging technique that uses molecules labeled with positron-emitting radionuclides to visualize and measure biochemical processes in the tissues of living subjects. In recent years, different PET tracers have been evaluated for their ability to characterize the atherosclerotic process in order to study the activity of the disease. Here, we describe detailed PET methods for preclinical studies of atherosclerosis and summarize the key methodological aspects of PET imaging in clinical studies of atherosclerosis.

Keywords: 18F-FDG; Autoradiography; In vivo positron emission tomography/computed tomography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Atherosclerosis* / diagnostic imaging
  • Fluorodeoxyglucose F18
  • Humans
  • Positron-Emission Tomography / methods
  • Radioisotopes / chemistry
  • Radiopharmaceuticals*


  • Radioisotopes
  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18