TRPM2-AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR-497-5p

Drug Dev Res. 2022 Jun;83(4):967-978. doi: 10.1002/ddr.21924. Epub 2022 Mar 2.

Abstract

Chemoresistance seriously hinders the treatment efficiency of human cancers, including prostate cancer (PCa). Multiple long noncoding RNAs (lncRNAs) were involved in drug resistance in PCa. We aimed to explore the function of transient receptor potential cation channel subfamily M member 2 (TRPM2) antisense RNA (TRPM2-AS) in paclitaxel (PTX) resistance in PCa. Our results showed that TRPM2-AS was increased in PTX-resistant PCa cells. TRPM2-AS knockdown accelerated cell apoptosis and inhibited cell proliferation, migration, invasion, and PTX resistance in PTX-resistant PCa cells. MiR-497-5p was bound to TRPM2-AS and its inhibition reversed the effects of TRPM2-AS knockdown on cell progression and PTX resistance in PTX-resistant PCa cells. FOXK1 was identified as a target of miR-497-5p and FOXK1 overexpression showed similar effects on cell progression and PTX resistance with miR-497-5p inhibition in PTX-resistant PCa cells. In conclusion, TRPM2-AS knockdown suppressed cell progression and PTX resistance in PTX-resistant PCa cells by miR-497-5p/FOXK1 axis.

Keywords: FOXK1; PTX resistance; TRPM2-AS; miR-497-5p; prostate cancer (PCa).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Drug Resistance, Neoplasm* / genetics
  • Forkhead Transcription Factors* / genetics
  • Forkhead Transcription Factors* / metabolism
  • Humans
  • Male
  • MicroRNAs* / genetics
  • Paclitaxel / pharmacology
  • Prostatic Neoplasms* / drug therapy
  • Prostatic Neoplasms* / genetics
  • RNA, Long Noncoding* / genetics
  • TRPM Cation Channels / genetics

Substances

  • FOXK1 protein, human
  • Forkhead Transcription Factors
  • MIRN497 microRNA, human
  • MicroRNAs
  • RNA, Long Noncoding
  • TRPM Cation Channels
  • TRPM2 protein, human
  • Paclitaxel