Bacteriostatic activity of bovine milk lactoferrin against mastitic bacteria

Vet Microbiol. 1986 Apr;11(4):387-92. doi: 10.1016/0378-1135(86)90068-4.


The bacteriostatic activity of bovine lactoferrin (Lf) against mastitic bacteria was assessed with an in vitro microassay. The most susceptible species was Escherichia coli; all of the 35 isolates tested were susceptible to bacteriostasis by apo-Lf (0.1 mg ml-1), although a few strains showed a lower degree of inhibition. Heterogeneity among strains was more pronounced among 10 isolates of Staphylococcus aureus, four of which were apparently unaffected by apo-Lf (1 mg ml-1). Under the same conditions, Streptococcus agalactiae (six isolates) and Str. uberis (five isolates) resisted the bacteriostatic action of apo-Lf.

MeSH terms

  • Animals
  • Cattle
  • Escherichia coli / growth & development
  • Lactoferrin / physiology*
  • Lactoglobulins / physiology*
  • Mastitis / microbiology*
  • Milk / microbiology*
  • Staphylococcus aureus / growth & development
  • Streptococcus / growth & development
  • Streptococcus agalactiae / growth & development


  • Lactoglobulins
  • Lactoferrin