Recycle before taking out the trash: ATG-9 exo-endocytosis links neuronal activity to autophagosome biogenesis

Neuron. 2022 Mar 2;110(5):735-737. doi: 10.1016/j.neuron.2022.01.037.


In this issue of Neuron, Yang et al. show that autophagy machinery is tightly coupled to neuronal activity via endocytic cycling of the transmembrane protein ATG-9 at presynaptic terminals.

Publication types

  • Comment

MeSH terms

  • Autophagosomes* / metabolism
  • Autophagy / physiology
  • Autophagy-Related Proteins / metabolism
  • Endocytosis* / physiology
  • Neurons / metabolism


  • Autophagy-Related Proteins