Recycle before taking out the trash: ATG-9 exo-endocytosis links neuronal activity to autophagosome biogenesis

Mónica C Quiñones-Frías; Avital A Rodal

doi:10.1016/j.neuron.2022.01.037

Recycle before taking out the trash: ATG-9 exo-endocytosis links neuronal activity to autophagosome biogenesis

Neuron. 2022 Mar 2;110(5):735-737. doi: 10.1016/j.neuron.2022.01.037.

Authors

Mónica C Quiñones-Frías¹, Avital A Rodal²

Affiliations

¹ Department of Biology, Brandeis University, Waltham, MA, USA.
² Department of Biology, Brandeis University, Waltham, MA, USA. Electronic address: arodal@brandeis.edu.

PMID: 35240059
DOI: 10.1016/j.neuron.2022.01.037

Abstract

In this issue of Neuron, Yang et al. show that autophagy machinery is tightly coupled to neuronal activity via endocytic cycling of the transmembrane protein ATG-9 at presynaptic terminals.

Publication types

Comment

MeSH terms

Autophagosomes* / metabolism
Autophagy / physiology
Autophagy-Related Proteins / metabolism
Endocytosis* / physiology
Neurons / metabolism

Substances

Autophagy-Related Proteins