COTA (colon-ovarian tumor antigen). An immunohistochemical study

Am J Clin Pathol. 1986 Jul;86(1):1-9. doi: 10.1093/ajcp/86.1.1.

Abstract

A goat anti-serum was prepared against mucinous ovarian cyst fluid and absorbed with normal colon and a variety of normal tissues until the only residual immunoreactivity was directed against colon cancer and ovarian tumor mucin. The set of antigenic determinants defined by this anti-serum has been called COTA, standing for colon-ovarian-tumor-antigen. This highly absorbed anti-serum (anti-COTA) was used for immunohistochemical staining of 42 different tissues in parallel with staining with a goat anti-CEA, which was also highly absorbed. The results suggest that COTA is a highly sensitive and specific antigen for colon carcinoma and may have potential for the early detection of malignant changes predictive of cancer of the colon.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenocarcinoma / diagnosis
  • Adenocarcinoma / immunology
  • Adenocarcinoma / pathology
  • Adenoma / diagnosis
  • Adenoma / immunology
  • Adenoma / pathology
  • Animals
  • Antibody Specificity
  • Antigens, Neoplasm / analysis*
  • Antigens, Neoplasm / immunology
  • Carcinoembryonic Antigen / analysis*
  • Carcinoembryonic Antigen / immunology
  • Colitis, Ulcerative / diagnosis
  • Colitis, Ulcerative / immunology
  • Colitis, Ulcerative / pathology
  • Colon / immunology
  • Colon / pathology
  • Colonic Neoplasms / diagnosis*
  • Colonic Neoplasms / immunology
  • Colonic Neoplasms / pathology
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Neoplasm Transplantation
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / immunology
  • Ovarian Neoplasms / pathology
  • Rats
  • Rats, Inbred Strains

Substances

  • Antigens, Neoplasm
  • Carcinoembryonic Antigen
  • colon-ovarian tumor antigen, human