Starving lethal prostate cancer by targeting heat shock proteins and glycolytic enzymes

Cell Rep Med. 2022 Feb 15;3(2):100493. doi: 10.1016/j.xcrm.2021.100493.

Abstract

Metastatic prostate cancer remains uncurable. In this issue of Cell Reports Medicine, Rice et al. present an assessment of a compound (SU086) demonstrating activity in prostate cancer models through heat shock protein 90 inhibition and cell metabolism changes.

Publication types

  • News
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Glycolysis
  • HSP90 Heat-Shock Proteins
  • Heat-Shock Proteins*
  • Humans
  • Inhibition, Psychological
  • Male
  • Prostatic Neoplasms* / drug therapy

Substances

  • HSP90 Heat-Shock Proteins
  • Heat-Shock Proteins