The therapeutic effect of granulocyte colony stimulating factor (G-CSF) on potential biochemical pregnancy in patients with unexplained repeated transplantation failure (RIF): a case series and literature review

Gynecol Endocrinol. 2022 May;38(5):443-447. doi: 10.1080/09513590.2022.2036716. Epub 2022 Mar 4.

Abstract

Background: Biochemical pregnancy is a type of embryo transfer failure, patients with unexplained repeated implantation failure (RIF) also have higher biochemical pregnancy rate. Our study intends to evaluate the effect of granulocyte colony-stimulating factor (G-CSF) in patients with unexplained RIF with low hCG levels in early pregnancy.

Methods: Unexplained RIF patients with low hCG levels after embryo transfer were allocated. G-CSF were administrated from the ninth days after embryo transfer. Clinical pregnancy, miscarriage and live birth rates were evaluated.

Results: The clinical pregnancy and live birth rates were 52.5% and 30%.

Conclusion: G-CSF is an effective treatment for potential biochemical pregnancy in unexplained RIF patients.

Keywords: Repeated implantation failure (RIF); biochemical pregnancy; clinical pregnancy rate; granulocyte colony-stimulating factor (G-CSF); live birth rate.

Publication types

  • Review

MeSH terms

  • Birth Rate
  • Embryo Implantation*
  • Embryo Transfer*
  • Female
  • Granulocyte Colony-Stimulating Factor / pharmacology
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Humans
  • Pregnancy
  • Pregnancy Rate

Substances

  • Granulocyte Colony-Stimulating Factor