Daily Clinical Practice in the Management of Chronic Urticaria in Spain: Results of the UCREX Study

M Ferrer Puga; J F Silvestre Salvador; J Bartra Tomas; A Giménez-Arnau; M Labrador-Horrillo; J Miquel-Miquel; F J Ortiz de Frutos; J Sastre Dominguez; A Valero Santiago; P Terradas-Montana; M Vidal-Jorge; I Jáuregui Presa

doi:10.1016/j.ad.2021.06.014

Daily Clinical Practice in the Management of Chronic Urticaria in Spain: Results of the UCREX Study

Actas Dermosifiliogr. 2022 Jan;113(1):4-14. doi: 10.1016/j.ad.2021.06.014. Epub 2022 Feb 3.

[Article in English, Spanish]

Affiliations

¹ Servicio de Alergología, Clínica Universidad de Navarra, Pamplona, Spain. Electronic address: mferrerp@unav.es.
² Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain.
³ Sección de Alergología, Servicio de Neumología, Hospital Clínic, IDIBAPS, ARADyAL, Universitat de Barcelona, Barcelona, Spain.
⁴ Servicio de Dermatología, Hospital del Mar, Parc de Salut Mar, Universitat Autònoma Barcelona, Barcelona, Spain.
⁵ Servicio de Alergología, Hospital Vall d'Hebron, VHIR, Universitat Autònoma Barcelona, ARADyAL (ISCIII), Barcelona, Spain.
⁶ Servicio de Dermatología, Hospital Arnau de Vilanova, Valencia, Spain.
⁷ Servicio de Dermatología, Hospital Universitario 12 de Octubre, Madrid, Spain.
⁸ Servicio de Alergología, Fundación Jiménez Diaz, Departamento de Medicina, Universidad Autónoma de Madrid, Spain.
⁹ Novartis Farmacéutica, Barcelona, Spain.
¹⁰ Servicio de Alergología, Hospital Universitario Cruces, Vizcaya, Spain.

PMID: 35244542
DOI: 10.1016/j.ad.2021.06.014

Abstract

Background: Chronic Urticaria (CU) is a debilitating disease whose treatment is mainly symptomatic. UCREX study aimed to identify CU patients' profile, disease management and quality-of-life (QoL) in daily clinical practice in Spain.

Methods: Observational, 12-months prospective, multicenter study, included de novo or established CU patients attending to dermatology/allergy consultations in 39 Spanish hospitals.

Main variables: Urticaria Activity Score (UAS), UAS over 7 days (UAS7). Secondary variables: CU-QoL Questionnaire (CU-Q₂oL), EuroQol-5 dimensions (EQ-5D), Medical Outcomes Study Sleep (MOS-Sleep) scale, Hospital Anxiety and Depression Scale (HADS).

Results: 361 patients included. Of them, 176 (48.8%) considered for the main objective analysis. Mean age (SD) of 46.6 (14.2) years and 71.8% women. The year prior to inclusion, most patients (57.1%) were treated with non-sedating H1-antihistamines (NS-H1AH). At baseline, mean (SD) 3.6 (6.8) visits were registered to primary care. Mean (SD) UAS7 at baseline was 14.3 (11.0) and CU-Q₂oL 24.1 (17.0) which tended to improve by 8.6 (9.7) and 13.9 (15.0), respectively, at 12-months. MOS-Sleep and EQ-5D remained steady during the study, except pain/discomfort and anxiety/depression which went from 58.7% and 49.6% to 29.6% and 26.9%, respectively. At baseline, HADS showed a mean (SD) anxiety of 8.7 (4.5) and depression 5.1 (4.4), decreasing to 7.0 (4.3) and 4.7 (4.3), respectively, at 12-months.

Conclusions: Although most CU patients are treated with NS-H1AH, disease activity is still important, negatively affecting patients' QoL, work activity and healthcare resources use. An appropriate disease management could be the basis for symptoms control, QoL improvement and resources optimization.

Keywords: Angioedema; Autoimmunity; Autoinmunidad; Calidad de vida; Dermatology; Dermatología; Epidemiology; Epidemiología; Quality-of-life; Urticaria.