Changing face of pulmonary embolism with COVID-19

Cardiovasc J Afr. 2023;34(1):4-8. doi: 10.5830/CVJA-2022-011. Epub 2022 Mar 4.

Abstract

Aim: This study aimed to describe the baseline characteristics of coronavirus disease 2019 (COVID-19) patients with pulmonary embolism, and to examine the Geneva score, pulmonary embolism severity index (PESI), radiological and biochemical findings.

Methods: From March 2020 to June 2021, the files of 41 COVID-19 patients with pulmonary embolism were accessed.

Results: Mean D-dimer value was 6.04 mg/dl and 61% of the patients received at least one dose of anticoagulant treatment. In patients receiving deep venous thrombosis prophlaxis, an optimal D-dimer cut-off point was calculated as 5.69 mg/dl. The area under the curve was 0.753 (p = 0.007; sensivity 64%; specificity 62.5%). The mean Geneva score was 4.31, mean PESI was 72.48 and mean Qanadli score was 11.29.

Conclusions: According to this study, traditional clinical predictive scores had little discriminatory power in these patients, and a higher D-dimer cut-off value should be considered to better diagnose patients for pulmonary embolism.

Keywords: pulmonary embolism; COVID‐19; D‐dimer; anticoagulant therapy; thrombosis.

MeSH terms

  • Anticoagulants / therapeutic use
  • COVID-19* / complications
  • Fibrin Fibrinogen Degradation Products
  • Humans
  • Pulmonary Embolism* / diagnostic imaging
  • Pulmonary Embolism* / drug therapy
  • Retrospective Studies

Substances

  • Anticoagulants
  • Fibrin Fibrinogen Degradation Products