Too much and not enough: tuning human primary T cell cytokine signaling networks

Sarah E Henrickson

doi:10.1126/sciimmunol.abo7677

Too much and not enough: tuning human primary T cell cytokine signaling networks

Sci Immunol. 2022 Mar 4;7(69):eabo7677. doi: 10.1126/sciimmunol.abo7677. Epub 2022 Mar 4.

Author

Sarah E Henrickson¹

Affiliation

¹ Children's Hospital of Philadelphia, Division of Allergy Immunology, Department of Pediatrics and Department of Microbiology Perelman School of Medicine, University of Pennsylvania, PA 19104 USA. Email: henricksons@chop.edu.

PMID: 35245087
DOI: 10.1126/sciimmunol.abo7677

Abstract

Combining CRISPR activation and interference screens to perturb cytokine secretion in primary human T cells clarifies regulation of cytokine production.

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MeSH terms

Clustered Regularly Interspaced Short Palindromic Repeats*
Cytokines
Humans
T-Lymphocytes*

Substances

Cytokines