The RTS,S vaccine-a chance to regain the upper hand against malaria?

Cell. 2022 Mar 3;185(5):750-754. doi: 10.1016/j.cell.2022.01.028.

Abstract

Malaria is estimated by the World Health Organization (WHO) to have killed 627,000 individuals worldwide in 2020, with nearly 80% of deaths in African children younger than five. The recent WHO approval of the RTS,S/AS01 vaccine, which targets Plasmodium falciparum pre-erythrocytic stages, provides hope that its use combined with other interventions can help reverse the current malaria resurgence.

MeSH terms

  • Child
  • Humans
  • Infant
  • Malaria Vaccines*
  • Malaria* / prevention & control
  • Malaria, Falciparum* / prevention & control
  • Plasmodium falciparum

Substances

  • Malaria Vaccines