Advanced Endoscopic Resection Techniques: Endoscopic Submucosal Dissection and Endoscopic Full-Thickness Resection

Dig Dis Sci. 2022 May;67(5):1521-1538. doi: 10.1007/s10620-022-07392-0. Epub 2022 Mar 4.


Endoscopic resection is first-line therapy in the management of superficial neoplasms throughout the gastrointestinal tract, as well as an increasingly viable therapeutic alternative in the resection of selected small deep lesions throughout the upper and lower gastrointestinal tract. The mainstay of therapy has traditionally been endoscopic snare polypectomy and endoscopic mucosal resection. However, recent innovative advancements in therapeutic endoscopy have provided for the ability to resect large superficial lesions and selected subepithelial lesions in en bloc and margin-negative fashion. In this review, we discuss the current state of the art in advanced endoscopic resection techniques including endoscopic submucosal dissection and endoscopic full-thickness resection.

Keywords: Endoscopic full-thickness resection; Endoscopic mucosal resection; Endoscopic resection; Endoscopic submucosal dissection; Endoscopic submucosal resection; Submucosal tunneling endoscopic resection.

Publication types

  • Review

MeSH terms

  • Endoscopic Mucosal Resection* / methods
  • Endoscopy
  • Gastrointestinal Tract
  • Humans