Reversal of insulin resistance is associated with repair of blood-brain barrier dysfunction and remission in a patient with treatment-resistant bipolar depression

Bipolar Disord. 2022 Aug;24(5):553-555. doi: 10.1111/bdi.13199. Epub 2022 Mar 13.

Authors

Cynthia Calkin^{1

2

3}, Lyna Kamintsky³, Alon Friedman^{3

4}

Affiliations

¹ Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
² Queen Elizabeth II Health Sciences Centre, Nova Scotia Health, Halifax, Nova Scotia, Canada.
³ Department of Medical Neuroscience, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
⁴ Departments of Cognitive and Brain Sciences, Physiology and Cell Biology, Ben-Gurion University of the Negev, Beer Sheva, Israel.

PMID: 35247029
DOI: 10.1111/bdi.13199

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bipolar Disorder* / complications
Bipolar Disorder* / drug therapy
Blood-Brain Barrier
Depressive Disorder, Treatment-Resistant* / drug therapy
Humans
Insulin Resistance*
Psychiatric Status Rating Scales