A double-blind gluten-free/gluten-load controlled trial in a secure ward population

Br J Psychiatry. 1986 Apr;148:447-52. doi: 10.1192/bjp.148.4.447.


A double-blind control trial of gluten-free versus a gluten-containing diet was carried out in a ward of maximum security hospital: 24 patients were studied for 14 weeks. Most suffered from psychotic disorders, particularly schizophrenia. Various dimensions of behaviour were rated on the Psychotic In-Patient profile (PIP) at different stages. There were beneficial changes in the whole group of patients between pre-trial and gluten-free period in five dimensions of the PIP, maintained during the gluten challenge period; these changes could be attributed to the attention the patients received. Two patients improved during the gluten-free period and relapsed when the gluten diet was reintroduced.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Clinical Trials as Topic
  • Double-Blind Method
  • Food Hypersensitivity / complications
  • Glutens / administration & dosage*
  • Glutens / adverse effects
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Psychotic Disorders / diet therapy*
  • Psychotic Disorders / etiology
  • Schizophrenia, Paranoid / diet therapy


  • Glutens