Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Simona Maria Migliano; Eva Maria Wenzel; Harald Stenmark

doi:10.1016/j.ceb.2022.01.007

Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Curr Opin Cell Biol. 2022 Apr:75:102062. doi: 10.1016/j.ceb.2022.01.007. Epub 2022 Mar 3.

Authors

Simona Maria Migliano¹, Eva Maria Wenzel¹, Harald Stenmark²

Affiliations

¹ Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway.
² Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Montebello, N-0379 Oslo, Norway; Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Montebello, N-0379 Oslo, Norway. Electronic address: stenmark@ulrik.uio.no.

PMID: 35248976
DOI: 10.1016/j.ceb.2022.01.007

Abstract

The endosomal sorting complex required for transport (ESCRT) machinery evolved early in evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed ESCRT-I, -II and -III, this machinery is recruited to various cellular locations to perform key steps in essential processes such as protein degradation, cell division, and membrane sealing. Here we review recent discoveries that have shed light on biophysical and molecular mechanisms of ESCRTs in endolysosomal protein degradation and nuclear envelope sealing, and we discuss how dysfunctional ESCRTs can lead to diseases such as cancer and neurodegenerative disorders.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biological Transport
Biophysics
Cell Movement
Endosomal Sorting Complexes Required for Transport*
Protein Transport

Substances

Endosomal Sorting Complexes Required for Transport