Cost-Effectiveness Analysis from a Societal Perspective of Recurrence Index for Distant Recurrence (RecurIndex) in Women with Hormone Receptor-Positive and HER2-Negative Early-Stage Breast Cancer

Nicolas Pennarun; Jian-Ying Chiu; Hsun-Chen Chang; Sean-Lin Huang; Skye Hung-Chun Cheng

doi:10.2147/CMAR.S339549

Cost-Effectiveness Analysis from a Societal Perspective of Recurrence Index for Distant Recurrence (RecurIndex) in Women with Hormone Receptor-Positive and HER2-Negative Early-Stage Breast Cancer

Cancer Manag Res. 2022 Feb 25:14:761-773. doi: 10.2147/CMAR.S339549. eCollection 2022.

Authors

Nicolas Pennarun¹, Jian-Ying Chiu², Hsun-Chen Chang³, Sean-Lin Huang¹, Skye Hung-Chun Cheng^{4

5}

Affiliations

¹ Amwise Diagnostics Pte. Ltd., Singapore.
² Department of Medical Operation, Amwise Diagnostics Pte. Ltd., Singapore.
³ Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
⁴ Department of Radiation Oncology, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan.
⁵ Cancer Center, Taitung Christian Hospital, Taitung, Taiwan.

Abstract

Purpose: A clinical-genomic prognostic multigene panel (RI-DR assay, RecurIndex^®), predicting the risk level of distant recurrence (DR) in early-stage breast cancer (EBC) patients with an Asian background, has been validated as a valuable tool for identifying high-risk patients to develop distant recurrence (metastasis). Although the clinical benefit of adjuvant chemotherapy from the assay's prediction is already proved, its affordability remains uncertain. This study is the first time in which the long-term cost-effectiveness of the RI-DR assay is evaluated.

Patients and methods: A lifetime Markov decision-analytic model was developed from a societal perspective to estimate the life-years gained (LYGs), quality-adjusted life-years (QALYs), medical costs, and incremental cost-effectiveness ratios (ICERs), comparing EBC women with and without RI-DR genomic testing. A decision tree was used to classify patients in one of the fifteen end nodes (by order, each arm was stratified by a patient being tested or not with the RI-DR assay, being treated or not with adjuvant chemotherapy and had no, minor, major, or fatal toxicity after adjuvant chemotherapy). Health utilities, costs, transition probabilities, and survival data were extracted from the scientific literature. Deterministic sensitivity analysis (DSA) and probabilistic sensitivity analysis (PSA) were performed on variables to assess the robustness of the model. A willingness-to-pay (WTP) threshold of 790,000 NT$ per QALY gained was considered as a cost-effectiveness criterion.

Results: The incremental cost per QALY gained under base-case assumptions of the model was 173,842 NT$. Findings on the variation in model input parameters were robust and confirmed that every key variable was cost-effective for the benefit of RI-DR testing.

Conclusion: The clinical-genomic RI-DR assay is cost-effective in guiding adjuvant chemotherapy decisions compared to current clinical practice guidelines.

Keywords: Markov model; RI-DR assay; decision making; economic evaluation; gene signature.

Grants and funding

This work was supported by Amwise Diagnostics Pte. Ltd. [grant number AMW0804].