Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes

Georg A Busslinger

doi:10.1080/23723556.2022.2026559

Barrett's esophagus stages: their correlation with SBS17-associated DNA mutations and the identification of histological marker genes

Mol Cell Oncol. 2022 Jan 22;9(1):2026559. doi: 10.1080/23723556.2022.2026559. eCollection 2022.

Author

Georg A Busslinger^{1

2}

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
² Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences, Vienna, Austria.

Abstract

We have recently reported a correlation between the accumulation of specific T > C and T > G mutations and the chromosomal instability in cells of Barrett's esophagus (BE), which represents a premalignant condition of esophageal adenocarcinoma. Additionally, we identified seven marker genes that facilitate the distinction of individual BE stages by histopathological examination.

Keywords: Barrett's esophagus; single-base substitution 17 (SBS17A and SBS17B); single-cell RNA and DNA analyses.

Grants and funding

The author(s) reported there is no funding associated with the work featured in this article.