Coronavirus disease 2019 and vaccination in patients with Shwachman-Diamond syndrome

Pediatr Blood Cancer. 2022 May;69(5):e29647. doi: 10.1002/pbc.29647. Epub 2022 Mar 6.


Because they can experience neutropenia due to bone marrow failure, patients with Shwachman-Diamond syndrome (SDS) carry increased risk for serious infections compared with the general population; however, there has been a paucity of data on the incidence and severity of coronavirus disease 2019 (COVID-19) in patients with SDS. We compiled results from a survey distributed to participants in the SDS Registry in May-June 2021. In this report, we describe the characteristics and outcomes of patients with SDS who had COVID-19. Patients reported a short clinical course without significant complications or cytopenias. Additionally, COVID-19 vaccines were well tolerated with minor side effects.

Keywords: Bone marrow failure; COVID-19; general hematology; infections in immunocompromised hosts; infectious disease; vaccines; viral infection.

MeSH terms

  • Bone Marrow Diseases*
  • COVID-19 Vaccines / adverse effects
  • COVID-19* / complications
  • Exocrine Pancreatic Insufficiency*
  • Humans
  • Neutropenia*
  • Shwachman-Diamond Syndrome
  • Vaccination


  • COVID-19 Vaccines