Factors contributing to delayed childhood cancer care in low- and middle-income countries: A systematic review protocol

Pediatr Blood Cancer. 2022 May;69(5):e29646. doi: 10.1002/pbc.29646. Epub 2022 Mar 6.


Background: Significant disparities exist for timely access to cancer care for children, with the highest disparities in low- and middle-income countries (LMICs). This study aims to conduct a systematic review that identifies the factors contributing to delayed care of childhood cancers in LMICs.

Methods: We will conduct a systematic review with search strings compliant with the PICO framework: (1) the Population-children (aged 0-18 years) from LMICs; (2) the Exposure-factors contributing to timely childhood cancer care; (3) the Outcome-delays in childhood cancer care.

Discussion: Our study is an essential step to guide strategic interventions to assess the myriad of factors that prevent children from accessing timely cancer care in LMICs. The results will be submitted for publication in a peer-reviewed journal and shared with institutions related to the field.

Keywords: LMIC; cancer care; global health; pediatrics; systematic review.

MeSH terms

  • Child
  • Developing Countries*
  • Humans
  • Neoplasms* / therapy
  • Poverty
  • Systematic Reviews as Topic