Constrictive Pericarditis Revealing Rare Case of ALH Amyloidosis With Underlying Lymphoplasmacytic Lymphoma (Waldenstrom Macroglobulinemia)

Vivian V Ho; Jack W O'Sullivan; William J Collins; Errol Ozdalga; Caitlin F Bell; Neil D Shah; Mayil S Krishnam; Michael G Ozawa; Ronald M Witteles

doi:10.1016/j.jaccas.2022.01.007

Constrictive Pericarditis Revealing Rare Case of ALH Amyloidosis With Underlying Lymphoplasmacytic Lymphoma (Waldenstrom Macroglobulinemia)

JACC Case Rep. 2022 Mar 2;4(5):271-275. doi: 10.1016/j.jaccas.2022.01.007.

Authors

Vivian V Ho¹, Jack W O'Sullivan², William J Collins³, Errol Ozdalga³, Caitlin F Bell², Neil D Shah⁴, Mayil S Krishnam⁵, Michael G Ozawa⁶, Ronald M Witteles²

Affiliations

¹ Stanford University School of Medicine, Stanford, California, USA.
² Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California, USA.
³ Department of Medicine, Stanford University, Stanford, California, USA.
⁴ Division of Cardiovascular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
⁵ Department of Radiology/Cardiovascular Imaging, Stanford University, Stanford, California, USA.
⁶ Department of Pathology, Stanford University, Stanford, California, USA.

Abstract

We present a case of pericardial amyloidosis with associated lymphoplasmacytic lymphoma in a patient with chronic worsening shortness of breath and cough. This case highlights the wide variation in the presentation of cardiac amyloidosis, and the rare occurrence of clinically significant light-chain and heavy-chain amyloidosis in the pericardium. (Level of Difficulty: Advanced.).

Keywords: AH, heavy chain form of amyloidosis; AL, light chain form of amyloidosis; ALH, light-chain and heavy-chain amyloidosis; CMR, cardiac magnetic resonance imaging; ECG, electrocardiogram; TTE, transthoracic echocardiography; cancer; cardiac magnetic resonance; constrictive; electrocardiogram; imaging; pericardial effusion.

Publication types

Case Reports