A stable start: cotranslational Nt-acetylation promotes proteome stability across kingdoms

Abstract

Two recent studies show that cotranslational N-terminal protein acetylation (NTA) promotes proteome stability in humans (Mueller et al.) and plants (Linster et al.) by masking nonacetylated N-degrons that would otherwise destabilise proteins. This is in contrast to previous findings linking NTA to degradation, suggesting that this widespread mark has complex and context-specific functions in regulating protein half-lives.

Keywords: N terminus; N-degron pathway; acetylation; cotranslational modification; proteolysis; proteostasis.