Hyperlipidemia and risk for preclampsia

J Clin Lipidol. 2022 May-Jun;16(3):253-260. doi: 10.1016/j.jacl.2022.02.005. Epub 2022 Feb 20.


Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality in the US. Preeclampsia (PreE) which includes hypertension and proteinuria during pregnancy, is thought to result from placental ischemia. Risk factors for PreE parallel those for cardiovascular disease, and recent studies point to hyperlipidemia specifically, hypertriglyceridemia, as a risk factor for PreE. Current practice does not routinely include lipid testing pre-conception or during pregnancy. Professional, societal recommendations should advocate for hyperlipidemia screening, followed by appropriate management, pre-conception and during pregnancy.

Keywords: Hypertriglyceridemia; Lipid testing; Maternal morbidity; Preeclampsia; Pregnancy.

Publication types

  • Review

MeSH terms

  • Female
  • Humans
  • Hyperlipidemias* / complications
  • Hyperlipidemias* / epidemiology
  • Hypertension* / complications
  • Placenta
  • Pre-Eclampsia* / diagnosis
  • Pre-Eclampsia* / epidemiology
  • Pre-Eclampsia* / etiology
  • Pregnancy
  • Proteinuria / complications
  • Risk Factors