Background: Premenopause and menopause are nowadays a matter of public health due to the increasing life expectancy for women. Medical issues related to the period of premenopause and menopause are important, since they can alter the quality of women's life. Objectives:The goal of this prospective study is to determine the effect of an original formula consisting of phytoestrogens extracted from soy germs (Glycyne hisipida) with 40% isoflavones, vitamin E and grapeseed extract (Vitis vinifera) with 95% proanthocyanidins in reducing menopausal symptoms. Materials and methods: The present study had a six-month monitoring period in 2011 and involved four investigating physicians from "Bega" Clinical Hospital of Obstetrics and Gynecology, Timisoara, Romania. Outcomes: After six months of therapy there was a percentually decrease in menopause symptoms (irritability, depression, anxiety, hot flashes, etc); the most dramatic changes in the symptomatology of these women were noticed among premenopausal subjects. Conclusion:The original formula consisting of phytoestrogen, vitamin E and grapeseed extract can be applied in premenopause and surgically-induced menopause, and it is beneficial by decreasing the intensity of the symptomatology.