Monocytes asphyxiate germinal centers

Yuke He; Carola G Vinuesa

doi:10.1016/j.immuni.2022.02.007

Monocytes asphyxiate germinal centers

Immunity. 2022 Mar 8;55(3):385-387. doi: 10.1016/j.immuni.2022.02.007.

Authors

Yuke He¹, Carola G Vinuesa²

Affiliations

¹ Centre for Personalised Immunology (CACPI), Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, 200001, China.
² Centre for Personalised Immunology (CACPI), Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, 200001, China; Francis Crick Institute, 1 Midland Rd, London NW1 1AT, United Kingdom; Department of Immunology and Infection, John Curtin School of Medical Research, Australian National University, 131 Garran Rd, Acton 2601, ACT, Australia. Electronic address: carola.vinuesa@crick.ac.uk.

PMID: 35263564
DOI: 10.1016/j.immuni.2022.02.007

Abstract

Some bacteria and parasites, such as Salmonella, actively disrupt germinal centers and elicit only low affinity antibodies, but the mechanisms by which microbes alter these responses is poorly understood. In this issue of Immunity, Biram et al. (2022) uncover a mechanism by which Salmonella recruits Sca-1⁺ monocytes to germinal centers and impairs metabolic adaptation.

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MeSH terms

Bacterial Infections*
Germinal Center / immunology
Humans
Monocytes*
Salmonella