Fungal infections in patients with AIDS and AIDS-related complex

Scand J Infect Dis. 1986;18(3):179-92. doi: 10.3109/00365548609032326.


PIP: Persons with AIDS are predisposed to a variety of previously rare bacterial and fungal infections. Improvement in the quality and duration of survival of AIDS patients depends on the efficacy of treatment for these infections. Between 58-81% of AIDS patients contract fungal infections at some time, and 10-20% of AIDS patients die as a direct consequence of such infections. Oral candidiasis, commonly known as thrush, is the most common fungal infection among AIDS and AIDS Related Complex patients, occurring in 80-90% of cases. In a recent U.S. study, 59% of persons with oral candidiasis who were at high risk of contracting AIDS went on to develop Kaposi's sarcoma and other life- threatening infections. The most common life-threatening fungal infection experienced by AIDS patients is cryptococcosis, a disease occurring among 6% of American AIDS patients and having a mortality rate of 17% during initial infections and 75-100% on relapse. Other opportunistic infections associated with AIDS and AIDS Related Complex are bronchial candidiasis, invasive aspergillosis, disseminated histoplasmosis, and disseminated coccidioidomycosis. All are treatable but eradication i s difficult and relapse common.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology*
  • Africa
  • Candidiasis / epidemiology
  • Candidiasis / immunology
  • Cryptococcosis / epidemiology
  • Cryptococcosis / immunology
  • Europe
  • Female
  • Histoplasmosis / epidemiology
  • Histoplasmosis / immunology
  • Humans
  • Male
  • Mycoses / immunology*
  • Prospective Studies
  • Retrospective Studies
  • Risk
  • United States