Amlodipine improves the outcomes of regorafenib in metastatic colorectal cancer

Anticancer Drugs. 2022 Apr 1;33(4):389-393. doi: 10.1097/CAD.0000000000001273.


Regorafenib is a multikinase inhibitor. It is used for metastatic colorectal cancer (mCRC) treatment. It has a mild effect. Regorafenib outcomes, and side effects may vary across patients. This study was aimed to evaluate the factors that affect regorafenib outcomes in mCRC patients. We conducted a single-center and retrospective study. Fifty-six patients were included. All patients had received regorafenib for mCRC. Some clinical and pathological factors and the effects of these factors on overall survival (OS), progression-free survival (PFS), and disease control rates (DCR) were analyzed. Concomitant amlodipine intake with regorafenib improved OS [14.26 vs. 6.97 months; 95% confidence interval, 4.04-20.84; P = 0.031] and DCR at 12th week (90% vs. 46%; P = 0.012). Hepatic metastasis was found as the poorest prognostic factor in both univariate and multivariate analyses. Patients who received chemotherapy after regorafenib had better OS. Good performance status was the strongest indicator of better OS. Patients taking amlodipine for arterial hypertension at the same time with regorafenib had numerically better OS and PFS and statistically better DCR. Amlodipine itself already has anticancer effects, and it has additive anticancer effects with regorafenib. The presence of hepatic metastases was found to be the most important prognostic factor for OS. There were not any predictive factors of side effects to regorafenib.

MeSH terms

  • Amlodipine / adverse effects
  • Colonic Neoplasms* / drug therapy
  • Colorectal Neoplasms* / pathology
  • Humans
  • Liver Neoplasms* / drug therapy
  • Liver Neoplasms* / secondary
  • Phenylurea Compounds / adverse effects
  • Pyridines
  • Rectal Neoplasms* / drug therapy
  • Retrospective Studies
  • Survival Rate


  • Phenylurea Compounds
  • Pyridines
  • Amlodipine
  • regorafenib