Chronic Neutropenia in Childhood: Laboratory and Clinical Features

Indian J Pediatr. 2022 Sep;89(9):894-898. doi: 10.1007/s12098-022-04104-4. Epub 2022 Mar 10.

Abstract

Objectives: To describe the clinical characteristics of patients with chronic neutropenia.

Methods: Data of 36 patients with chronic neutropenia, who were followed up in the authors' clinic between May 2013 and May 2020, were analyzed retrospectively. Patients were diagnosed based on their clinical and laboratory characteristics.

Results: A total of 36 patients (23 females, 13 males) were included in the study. The mean age at diagnosis was 9.85 ± 9.17 mo while the mean follow-up time was 21.83 ± 20.03 mo. The mean absolute neutrophil count (ANC) at admission was 462.5 ± 388.8 cells/mm3 (median = 375 cells/mm3), and the lowest and highest ANC mean was 241.2 ± 262.1 cells/mm3 (median = 125 cells/mm3), and 1362.9 ± 1127.9 cells/mm3 (median = 925 cells/mm3), respectively. Idiopathic neutropenia was found in 28 (77.8%) patients, autoimmune neutropenia in 6 (16.7%) patients, and congenital neutropenia in 2 (5.6%) patients. Neutrophil normalization was observed in 19 (52.8%) of the patients.

Conclusions: Chronic neutropenia is a heterogeneous picture that presents with different clinical symptoms in childhood. The cause of neutropoenia in children is usually benign and resolves spontaneously but especially in those with severe neutropoenia genetic examination should be performed.

Keywords: Autoimmune neutropenia; Chronic neutropenia; Congenital neutropenia.

MeSH terms

  • Child
  • Female
  • Hospitalization
  • Humans
  • Leukocyte Count
  • Male
  • Neutropenia* / diagnosis
  • Neutropenia* / etiology
  • Neutrophils
  • Retrospective Studies