Overcoming drug resistance, the natural way

Matthew I Hutchings; Katherine R Duncan

doi:10.1016/j.chom.2022.02.008

Overcoming drug resistance, the natural way

Cell Host Microbe. 2022 Mar 9;30(3):273-274. doi: 10.1016/j.chom.2022.02.008.

Authors

Matthew I Hutchings¹, Katherine R Duncan²

Affiliations

¹ Department of Molecular Microbiology, John Innes Centre, Norwich Research Park, Norwich NR4 7TJ, UK.
² Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0RE, UK. Electronic address: katherine.duncan@strath.ac.uk.

PMID: 35271795
DOI: 10.1016/j.chom.2022.02.008

Abstract

Colistin is an antibiotic of last resort for treating Gram-negative bacterial infections, but resistance is spreading rapidly. In a recent issue of Nature, Wang et al. use genome mining to identify and synthesize a natural variant that bypasses colistin resistance and offers new hope for tackling antimicrobial resistance.

Publication types

Comment

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Colistin* / pharmacology
Colistin* / therapeutic use
Drug Resistance
Gram-Negative Bacterial Infections* / drug therapy
Humans

Substances

Anti-Bacterial Agents
Colistin