Debugging the gut-brain axis in depression

Cassandra E Gheorghe; John F Cryan; Gerard Clarke

doi:10.1016/j.chom.2022.02.007

Debugging the gut-brain axis in depression

Cell Host Microbe. 2022 Mar 9;30(3):281-283. doi: 10.1016/j.chom.2022.02.007.

Authors

Cassandra E Gheorghe¹, John F Cryan², Gerard Clarke³

Affiliations

¹ APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
² APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.
³ APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland; INFANT Research Centre, University College Cork, Cork, Ireland. Electronic address: g.clarke@ucc.ie.

PMID: 35271799
DOI: 10.1016/j.chom.2022.02.007

Abstract

In this issue of Cell Host & Microbe, Li et al. take a step toward a better understanding of the microbiome-gut-brain axis in mental health. They report gastrointestinal testosterone degradation by a specific bacterial strain as a potential mechanism impacting symptom expression in males with depression.

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MeSH terms

Bacteria / metabolism
Brain-Gut Axis*
Depression
Gastrointestinal Microbiome*