Early clues regarding the pathogenesis of long-COVID

Trends Immunol. 2022 Apr;43(4):268-270. doi: 10.1016/j.it.2022.02.008. Epub 2022 Mar 8.


Intense investigation into the predictors and determinants of post-acute sequelae of SARS-CoV-2 infection (PASC), including 'long COVID', is underway. Recent studies provide clues to the mechanisms that might drive this condition, with the goal of identifying host or virus factors that can be intervened upon to prevent or reverse PASC.

Keywords: SARS-CoV-2; immunology; long COVID; post-acute COVID syndrome (PACS); post-acute sequelae of SARS-CoV-2 (PASC).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • COVID-19* / complications
  • Disease Progression
  • Humans
  • Post-Acute COVID-19 Syndrome
  • SARS-CoV-2