Early clues regarding the pathogenesis of long-COVID

Michael J Peluso; Steven G Deeks

doi:10.1016/j.it.2022.02.008

Early clues regarding the pathogenesis of long-COVID

Trends Immunol. 2022 Apr;43(4):268-270. doi: 10.1016/j.it.2022.02.008. Epub 2022 Mar 8.

Authors

Michael J Peluso¹, Steven G Deeks²

Affiliations

¹ Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA.
² Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA. Electronic address: steven.deeks@ucsf.edu.

Abstract

Intense investigation into the predictors and determinants of post-acute sequelae of SARS-CoV-2 infection (PASC), including 'long COVID', is underway. Recent studies provide clues to the mechanisms that might drive this condition, with the goal of identifying host or virus factors that can be intervened upon to prevent or reverse PASC.

Keywords: SARS-CoV-2; immunology; long COVID; post-acute COVID syndrome (PACS); post-acute sequelae of SARS-CoV-2 (PASC).

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19* / complications
Disease Progression
Humans
Post-Acute COVID-19 Syndrome
SARS-CoV-2