Outpatient transperineal prostate biopsy under local anaesthesia is safe, well tolerated and feasible

ANZ J Surg. 2022 Jun;92(6):1480-1485. doi: 10.1111/ans.17593. Epub 2022 Mar 10.


Background: Transperineal biopsy (TPB) of the prostate has been increasingly utilized as it has reduced infection risks. Traditionally however, it is performed under general anaesthesia, thus it carries a differing set of risks. Recently, new studies have performed TPB under local anaesthesia with success. In the present study, we explored our experience of performing TPB under local anaesthesia in an Australian cohort.

Methods: In this prospective study based at a metropolitan outpatient clinic, patients were provided with TPB under local anaesthesia. We assessed prostate cancer detection rates, complication rates and patient tolerability. Pain tolerability was assess using patient reported pain score on the visual analogue scale. Follow up data was collected at days 7 and 30 post-biopsy via telephone interview.

Results: A total of 48 patients were enrolled in this study between June 2020 and March 2021. Median age was 65.5 years and median PSA was 6.95 ng/mL. Clinically significant prostate cancer was detected in 58% of patients. During the procedure, pain scores were rated the highest during infiltration of local anaesthetic agent with a median score of 5. By the conclusion of the procedure, median pain score was 1. Vast majority of patients (85.4%) would opt for a repeat TPB under local anaesthesia should the need for prostate biopsy arise again. Two of our patients experienced infectious complications, and one experienced urinary retention.

Conclusion: Our data is in line with currently available data and confirms that TPB under local anaesthesia can be achieved in a safe and tolerable manner.

Keywords: clinically significant prostate cancer; complications; detection rate; local anaesthesia; prostate biopsy; transperineal biopsy.

MeSH terms

  • Aged
  • Anesthesia, Local
  • Australia / epidemiology
  • Biopsy / adverse effects
  • Biopsy / methods
  • Humans
  • Image-Guided Biopsy / methods
  • Male
  • Outpatients
  • Pain / etiology
  • Pain / pathology
  • Pain / prevention & control
  • Perineum / pathology
  • Prospective Studies
  • Prostate* / pathology
  • Prostatic Neoplasms* / pathology
  • Prostatic Neoplasms* / surgery

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