Unclassified Oncocytic Renal Neoplasm with Rib and Liver Metastases: Metastatic Oncocytoma?

Int J Surg Pathol. 2022 Oct;30(7):810-815. doi: 10.1177/10668969221084265. Epub 2022 Mar 11.


Renal tumors with oncocytic or chromophobe-like morphology can be a common source of diagnostic difficulty. In some series, they constitute the largest group of unclassified renal cell carcinomas, a term used for neoplasms that do not fit the current classification of renal tumors. We describe the histological, immunohistochemical, and molecular findings of an eosinophilic renal neoplasm which presented with rib and liver metastases, and provide a review of the literature. The possibility of a renal oncocytoma with metastases was initially considered but excluded on the basis of several morphological and immunohistochemical features. Additionally, the tumor did not correspond with other traditional or newly emerging categories of renal neoplasms. It was therefore regarded as an unclassified oncocytic renal neoplasm which demonstrated evidence of malignant potential due to the presence of multiple metastases.

Keywords: case report; metastatic oncocytic renal neoplasm; metastatic renal oncocytoma; oncocytic renal neoplasm; renal oncocytoma; unclassified renal cell carcinoma.

Publication types

  • Review

MeSH terms

  • Adenoma, Oxyphilic* / diagnosis
  • Adenoma, Oxyphilic* / pathology
  • Biomarkers, Tumor
  • Carcinoma, Renal Cell* / diagnosis
  • Carcinoma, Renal Cell* / pathology
  • Humans
  • Kidney Neoplasms* / diagnosis
  • Kidney Neoplasms* / pathology
  • Liver Neoplasms* / diagnosis
  • Ribs / pathology


  • Biomarkers, Tumor