Bilateral Intraparietal Activation for Number Tasks in Studies Using Adaptation Paradigm: A Meta-analysis

Neuroscience. 2022 May 10:490:296-308. doi: 10.1016/j.neuroscience.2022.02.024. Epub 2022 Mar 9.


Mathematical processing is important for professional success. The adaptation paradigm has been widely used to study the brain underpinnings of mathematical processing. In this study, we aim at shedding light on an important component of mathematical processing, namely numerical cognition. To do so, we performed a meta-analysis using the Activation Likelihood Estimation method on studies that have employed the adaptation paradigm for examining numerical cognition. We found a bilateral Intraparietal Sulcus (IPS) activation in studies using both symbolic and non-symbolic stimuli formats. We also found a right lateralized brain activation for the non-symbolic condition and a left lateralized brain activation for the symbolic condition. These results imply that the adaptation paradigm likely targets numeric magnitude processing and confirms the potency of this paradigm to activate the IPS.

Keywords: adaptation paradigm; fMRI; intraparietal sulcus; meta-analysis; symbolic vs. non-symbolic.

Publication types

  • Meta-Analysis
  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / physiology
  • Brain Mapping*
  • Magnetic Resonance Imaging* / methods
  • Mathematics
  • Parietal Lobe / physiology