The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review

Nutrients. 2022 Jan 29;14(3):591. doi: 10.3390/nu14030591.


Immune-mediated inflammatory skin diseases are characterized by a complex multifactorial etiology, in which genetic and environmental factors interact both in genesis and development of the disease. Nutrition is a complex and fascinating scenario, whose pivotal role in induction, exacerbation, or amelioration of several human diseases has already been well documented. However, owing to the complexity of immune-mediated skin disease clinical course and breadth and variability of human nutrition, their correlation still remains an open debate in literature. It is therefore important for dermatologists to be aware about the scientific basis linking nutrition to inflammatory skin diseases such as psoriasis, atopic dermatitis, hidradenitis suppurativa, bullous diseases, vitiligo, and alopecia areata, and whether changes in diet can influence the clinical course of these diseases. The purpose of this narrative review is to address the role of nutrition in immune-mediated inflammatory skin diseases, in light of the most recent and validate knowledge on this topic. Moreover, whether specific dietary modifications could provide meaningful implementation in planning a therapeutic strategy for patients is evaluated, in accordance with regenerative medicine precepts, a healing-oriented medicine that considers the whole person, including all aspects of the lifestyle.

Keywords: alopecia areata; atopic dermatitis; bullous diseases; diet; immune-mediated skin diseases; nutrition; psoriasis; suppurative hidradenitis; vitiligo.

Publication types

  • Review

MeSH terms

  • Alopecia Areata*
  • Dermatitis, Atopic* / drug therapy
  • Hidradenitis Suppurativa*
  • Humans
  • Psoriasis* / drug therapy
  • Vitiligo*