Effects of Weight Loss on Mechanisms of Hyperglycemia in Obese Non-Insulin-Dependent Diabetes Mellitus

Diabetes. 1986 Sep;35(9):990-8. doi: 10.2337/diab.35.9.990.

Abstract

To quantitate the effects of weight loss on the mechanisms responsible for hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM), eight obese subjects with NIDDM were studied before and after weight reduction with posttreatment assessment after 3 wks of isocaloric (weight maintenance) refeeding. After weight loss of 16.8 +/- 2.7 kg (mean +/- SE), the fasting plasma glucose level decreased 55% from 277 +/- 21 to 123 +/- 8 mg/dl. The individual fasting glucose levels were highly correlated with the elevated basal rates of hepatic glucose output (HGO) (r = 0.91, P less than .001), which fell from 138 +/- 11 to 87 +/- 5 mg X m-2 X min-1 after weight loss. The change in fasting plasma glucose also correlated significantly with the change in the basal rates of HGO (r = 0.74, P less than .05). This was associated with reduced fasting serum levels of glucagon (from 229 +/- 15 to 141 +/- 12 pg/ml), reduced free fatty acids (from 791 +/- 87 to 379 +/- 35 mu eq/L), and unchanged basal insulin levels (17 +/- 4 to 15 +/- 2 microU/ml).(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 3-O-Methylglucose
  • Adipose Tissue / metabolism
  • Animals
  • Blood Glucose / analysis
  • Body Weight*
  • Diabetes Mellitus / diet therapy
  • Diabetes Mellitus / physiopathology*
  • Diabetes Mellitus, Type 2 / diet therapy
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Dogs
  • Glucose / metabolism
  • Glucose Tolerance Test
  • Humans
  • Hyperglycemia / physiopathology*
  • Insulin / blood
  • Insulin / metabolism
  • Insulin Secretion
  • Male
  • Methylglucosides / metabolism
  • Middle Aged
  • Obesity*

Substances

  • Blood Glucose
  • Insulin
  • Methylglucosides
  • 3-O-Methylglucose
  • Glucose