Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study

Lindsey A Knake; Mhd Wael Alrifai; Allison B McCoy; Scott O Guthrie; Adam Wright; Christoph U Lehmann; L Dupree Hatch 3rd

doi:10.1038/s41372-022-01362-0

Factors associated with initial tidal volume selection during neonatal volume-targeted ventilation in two NICUs: a retrospective cohort study

J Perinatol. 2022 Jun;42(6):756-760. doi: 10.1038/s41372-022-01362-0. Epub 2022 Mar 12.

Authors

Lindsey A Knake^{1

2

3

4}, Mhd Wael Alrifai^{5

6

7}, Allison B McCoy^{6

7}, Scott O Guthrie^{5

8}, Adam Wright^{6

7}, Christoph U Lehmann⁹, L Dupree Hatch 3rd^{5

10

11}

Affiliations

¹ Department of Pediatrics, Division of Neonatology, University of Iowa, Iowa City, IA, USA. lindsey-knake@uiowa.edu.
² Department of Pediatrics, Division of Neonatology, Vanderbilt University Medical Center, Nashville, TN, USA. lindsey-knake@uiowa.edu.
³ Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA. lindsey-knake@uiowa.edu.
⁴ Vanderbilt Clinical Informatics Center, Vanderbilt University, Nashville, TN, USA. lindsey-knake@uiowa.edu.
⁵ Department of Pediatrics, Division of Neonatology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁶ Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
⁷ Vanderbilt Clinical Informatics Center, Vanderbilt University, Nashville, TN, USA.
⁸ Jackson-Madison County General Hospital, Jackson, TN, USA.
⁹ Clinical Informatics Center, University of Texas Southwestern Medical Center, Dallas, TX, USA.
¹⁰ Center for Child Health Policy, Vanderbilt University Medical Center, Nashville, TN, USA.
¹¹ Critical Illness, Brain Dysfunction, and Survivorship Center, Vanderbilt University Medical Center, Nashville, TN, USA.

Abstract

Objective: To quantify initial tidal volume (VT) during neonatal volume-targeted ventilation (VTV) and to characterize the agreement of initial VT with the limited-evidence available.

Study design: We performed a multi-center retrospective observational cohort study in two Neonatal Intensive Care Units evaluating 313 infants who received VTV as the initial ventilation modality prior to postnatal day 14. We generated descriptive statistics and performed multivariable logistic regression analysis to determine factors associated with initial VT use that agreed with available literature.

Results: 154 (49%) infants received an initial VT of 5.0 mL/kg (median 5.0 mL/kg, IQR 5.0-5.1). 45 (14%) infants received an initial VT that was congruent with available literature. A birth weight of 700 -<1250 g was significantly associated with an initial VT in agreement with VT literature (aOR 9.4, 95% CI 1.7-50.4).

Conclusions: Most infants receive an initial VT of 5.0 mL/kg.

Publication types

Observational Study
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Humans
Infant
Infant, Newborn
Intensive Care Units, Neonatal*
Lung
Respiration, Artificial*
Retrospective Studies
Tidal Volume

Abstract

Publication types

MeSH terms

Grants and funding