Extrafollicular proliferation of B-blasts: Morphologic correlate to Spikevax-induced lymphadenopathy

Clin Case Rep. 2022 Mar 2;10(3):e05398. doi: 10.1002/ccr3.5398. eCollection 2022 Mar.

Abstract

A 30-year-old male developed a PET-positive left-sided cervical lymphadenopathy that was suspected representing metastasis of a known right-sided papillary thyroid cancer. First-dose-application of Spikevax three weeks ago was neither reflected, nor reported to the pathologists. Diagnostic lymphadenectomy was performed showing extrafollicular proliferation of B-blasts, likely attributable to the vaccine application.

Keywords: COVID‐19; Spikevax; extrafollicular proliferation of B‐blasts; lymphadenopathy; mRNA vaccine.