Old macrophages lose their (circadian) rhythm

Trends Immunol. 2022 Apr;43(4):265-267. doi: 10.1016/j.it.2022.02.005. Epub 2022 Mar 10.


Blacher and colleagues have discovered that the circadian patterns of macrophage gene expression and immune function that exist in young mice are disrupted in aging mice. KLF4 was identified as a key transcription factor (TF) regulating rhythmic expression of immune genes, which is lost in old macrophages.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging*
  • Animals
  • Circadian Rhythm*
  • Gene Expression Regulation
  • Kruppel-Like Factor 4
  • Macrophages* / cytology
  • Mice
  • Transcription Factors / genetics


  • Klf4 protein, mouse
  • Kruppel-Like Factor 4
  • Transcription Factors