Binding of human fibrinogen to Candida albicans in vitro: a preliminary study

J Med Vet Mycol. 1986 Aug;24(4):345-8. doi: 10.1080/02681218680000511.

Abstract

The binding of human fibrinogen to different morphological forms of Candida albicans (blastoconidia, germ tubes and hyphae) was investigated by immunofluorescence and electron microscopy. Fibrinogen appeared to bind more strongly to hyphae than to yeast forms, and was detected on the cell wall coat. These observations suggest a possible role for fibrinogen in fungal colonization processes in vivo.

MeSH terms

  • Candida albicans / metabolism*
  • Candida albicans / ultrastructure
  • Fibrinogen / metabolism*
  • Fluorescent Antibody Technique
  • Humans
  • Microscopy, Electron

Substances

  • Fibrinogen