The Immunogenetics of Lichen Planus

Adv Exp Med Biol. 2022:1367:119-135. doi: 10.1007/978-3-030-92616-8_5.


Lichen planus (LP) is a multifaceted autoimmune disease affecting the skin, nails, hair, and mucous membranes, with several clinical subgroups. Cell-mediated immunity plays a key role in its progression. This chapter reviews the known genetic associations of lichen planus including HLA as well as non-HLA genes.

Keywords: Classic lichen plan; Cutaneous lichen plan; GWAS; Immunogenetics; Immunogenetics of lichen planus; Lichen planopilaris; Lichen planus; Mucosal lichen plan; Pathogenesis; Single nucleotide polymorphism.

MeSH terms

  • Autoimmune Diseases*
  • Hair
  • Humans
  • Immunogenetics
  • Lichen Planus* / genetics
  • Skin