Non-radical synthesis of chitosan-quercetin polysaccharide: Properties, bioactivity and applications

Carbohydr Polym. 2022 May 15:284:119206. doi: 10.1016/j.carbpol.2022.119206. Epub 2022 Jan 31.


Quercetin-chitosan (QCS) polysaccharide was synthesized via non-radical reaction using L-valine-quercetin as the precursor. QCS was systematically characterized and demonstrated amphiphilic properties with self-assembling ability. In-vitro activity studies confirmed that quercetin grafting does not diminish but rather increases antimicrobial activity of the original chitosan (CS) and provided the modified polysaccharide with antioxidative properties. QCS applied as a coating on fresh-cut fruit reduced microbial spoilage and oxidative browning of coated melon and apple, respectively. Notably, QCS-based coatings prevented moisture loss, a major problem with fresh produce (2%, 12% and 18% moisture loss for the QCS-coated, CS-coated and uncoated fruit, respectively). The prepared QCS polysaccharide provides advanced bioactivity and does not involve radical reactions during its synthesis, therefore, it has good potential for use as a nature-sourced biocompatible active material for foods and other safety-sensitive applications.

Keywords: Active coating; Antimicrobial; Antioxidant; Chitosan; Non-radical grafting; Quercetin.

MeSH terms

  • Antioxidants / pharmacology
  • Chitosan*
  • Cucurbitaceae*
  • Polysaccharides / pharmacology
  • Quercetin / pharmacology


  • Antioxidants
  • Polysaccharides
  • Chitosan
  • Quercetin