A Low rectal GIST

BMJ Case Rep. 2022 Mar 14;15(3):e248505. doi: 10.1136/bcr-2021-248505.


A man in his 70s presented with narrowing of his stool calibre and a palpable mass on rectal examination. Colonoscopy revealed a submucosal bulge without a mucosal lesion. CT and MRI demonstrated an 8×5.4×7 cm mass in lower rectum. Biopsy of the mass confirmed a rectal gastrointestinal stromal tumour (GIST). It was moderately sensitive to neoadjuvant imatinib and radiotherapy, which slightly downsized the tumour. He required abdominal perineal resection with curative intent. Uncommonly found in the rectum, when located here, GISTs are typically aggressive and are a rare cause of stool calibre narrowing. Rectal GISTs should be considered in patients presenting with this symptom.

Keywords: gastrointestinal surgery; gastrointestinal system; malignant disease and immunosuppression; radiology (diagnostics).

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents* / therapeutic use
  • Gastrointestinal Stromal Tumors* / diagnostic imaging
  • Gastrointestinal Stromal Tumors* / surgery
  • Humans
  • Imatinib Mesylate / therapeutic use
  • Male
  • Rectal Neoplasms* / drug therapy
  • Rectal Neoplasms* / surgery
  • Rectum / diagnostic imaging
  • Rectum / pathology
  • Rectum / surgery


  • Antineoplastic Agents
  • Imatinib Mesylate