Malignant Hypertension: Current Perspectives and Challenges

J Am Heart Assoc. 2022 Apr 5;11(7):e023397. doi: 10.1161/JAHA.121.023397. Epub 2022 Mar 15.


Malignant hypertension is a hypertensive emergency, with rapid disease progression and poor prognosis. Although recognized as a separate entity more than a century ago, significant knowledge gaps remain about its pathogenesis and treatment. This narrative review summarizes current viewpoints, research gaps, and challenges with a view to pooling future efforts at improving treatment and prognosis.

Keywords: basic science; clinical research; hypertensive emergency; malignant hypertension.

Publication types

  • Editorial
  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Disease Progression
  • Humans
  • Hypertension* / diagnosis
  • Hypertension* / epidemiology
  • Hypertension* / therapy
  • Hypertension, Malignant* / diagnosis
  • Hypertension, Malignant* / drug therapy
  • Hypertension, Malignant* / epidemiology
  • Prognosis


  • Antihypertensive Agents